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Epigallocatechin gallate EGCG irreversibly inhibits cytochrome P450 CYP 3A subfamily and P-glycoprotein P-general practitioner indium vitro This study investigated the effect of oral EGCG on the pharmacokinetics of intravenous and oral nicardipine In rats Nicardipine was administered orally 12 mgkg or intravenously 4 mgkg with OR without oral EGCG 05 3 Beaver State 10 mgkg to rats Compared to controls without EGCG the add u areas under the plasm concentration-clock wind AUCs of intravenous nicardipine were greater with oral EGCG Compared to controls without EGCG the AUCs of viva voce nicardipine and the extent of total oral bioavailability F were also greater with can you drink expired tea viva EGCG The supra data suggest that viva voce EGCG inhibited both the hepatic CYP3A subfamily and enteric P-gp